Federal regulations require that all NIH grants involving vertebrate animals be reviewed by the Institutional Animal Care and Use Committee (IACUC). The IACUC approval date on the grant application must be listed as "pending" until the Committee has had an opportunity to formally conduct a grant comparison with the IACUC protocol application and provide approval.
The grant application must address the following five points in Section F:
- Provide a detailed description of the proposed use of the animals in the work outlined in the Research Design and Methods section. Identify the species, strains, ages, sex, and numbers of animals to be used in the proposed work.
- Justify the use of animals, the choice of species, and the numbers to be used. If animals are in short supply, costly, or to be used in large numbers, provide an additional rationale for their selection and numbers.
- Provide information on the veterinary care of the animals involved.
- Describe the procedures for ensuring that discomfort, distress, pain, and injury will be limited to that which is unavoidable in the conduct of scientifically sound research. Describe the use of analgesic, anesthetic, and tranquilizing drugs and/or comfortable restraining devices, where appropriate, to minimize discomfort, distress, pain, and injury.
- Describe any method of euthanasia to be used and the reasons for its selection. State whether this method is consistent with the recommendations of the Panel on Euthanasia of the American Veterinary Medical Association. If not, present a justification for not following the recommendations.
Please be aware that approval must be granted prior to award of funds. Some agencies may require earlier notification of approval. Once notified by NIH of the funding status, investigators must follow one of the following procedures:
Funding for new and already approved IACUC protocols
When submitting a new protocol in EnCCoMPass it should describe the animal use activities as proposed in the grant or contract, including the scientific rationale, hypothesis, species, number of animals, methods, and staff utilized. Please make sure these conditions are met in order to receive an approval. Once the new protocol is approved that approval letter would be used as the Grant Verification.
Alternatively, if you have an approved protocol(s) that meets the criteria described above except the funding agency and grant/contract # were not included in the protocol(s) then you need to submit an amendment and add the grant(s) which are supported by the protocol. The grant would be added in the “Sponsorship” section of the protocol under GI.04. Once that amendment is approved the amendment approval letter would be used as the Grant Verification.
NOTE: If the project involves a collaboration with an investigator at another institution and that investigator will be conducting the animal work, you will need to complete an application for an IACUC Collaborative Project. This will require submission of an approved protocol from the collaborating institution. Please contact the IACUC Coordinator (646-962-2982) for clarifications.
If the grant involves the use of rDNA or transgenic animals, the form "Certificate of Registration for Research Using Recombinant DNA or Transgenic Animals" must be completed. The form can be obtained from the IBC website.